2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W703376
    2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride 63199-74-6 98%
    2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride (Compound Imp.1) is a non-selective monoamine transporter (DAT/NET/SERT) agonist. tert-Butylcathinone hydrochloride is promising for research of depressive disorders.
    2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride
  • HY-W704752
    Z-Doxepin-d3 Hydrochloride 2469242-68-8 98%
    Z-Doxepin-d3 hydrochloride is the deuterium labeled 7-Hydroxychlorpromazine hydrochloride (HY-W704749). 7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine hydrochloride can increase prolactin levels in rats. 7-Hydroxychlorpromazine hydrochloride can increase dopamine turnover and has a sedative effect. In addition, 7-Hydroxychlorpromazine hydrochloride can effectively inhibit amphetamine-induced stereotyped behavior in rats and is used in the study of psychosis.
    Z-Doxepin-d3 Hydrochloride
  • HY-W704786
    Prilocaine Hydrochloride-d7 2509098-78-4 98%
    Prilocaine Hydrochloride-d7 is the deuterium labeled Prilocaine hydrochloride (HY-B0137A). Prilocaine hydrochloride, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects.
    Prilocaine Hydrochloride-d7
  • HY-W704807
    3-Methoxytyramine-d3 hydrochloride 2409015-09-2 98%
    3-Methoxytyramine-d3 hydrochloride (3-O-methyl Dopamine-d3 hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride (HY-103638). 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).
    3-Methoxytyramine-d3 hydrochloride
  • HY-W704876
    Procaine hydrochloride-d4 98%
    Procaine hydrochloride-d4 is the deuterium labeled Procaine hydrochloride (HY-B0546A). Procaine hydrochloride is a DNA-demethylating agent. Procaine hydrochloride acts through multiple targets and has a slow onset and a short duration of action.
    Procaine hydrochloride-d4
  • HY-W707158
    Norfenfluramine hydrochloride 673-18-7 98%
    Norfenfluramine hydrochloride ((±)-Norfenfluramine hydrochloride) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine hydrochloride can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine hydrochloride displays antiepileptic effects in vivo.
    Norfenfluramine hydrochloride
  • HY-W707161
    4-Methyl-2-(1-piperidinyl)-quinoline-d10 2733721-10-1 98%
    4-Methyl-2-(1-piperidinyl)-quinoline-d10 is the deuterium labeled ML204 (HY-12949). ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels.
    4-Methyl-2-(1-piperidinyl)-quinoline-d10
  • HY-W707498
    Baclofen-d4-1 70155-52-1 98%
    Baclofen-d4-1 is the deuterium labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research.
    Baclofen-d4-1
  • HY-W707528
    Propofol-d14 2514564-65-7 98%
    Propofol-d14 (2,6-Diisopropylphenol-d14) is the deuterium labeled Propofol (HY-B0649). Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic.
    Propofol-d14
  • HY-W707539
    Carisbamate-d2,-15N 98%
    Carisbamate-d2,-15N (RWJ-333369-d2,-15N) is the deuterium labeled Carisbamate (HY-14948). Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy.
    Carisbamate-d2,-15N
  • HY-W707693
    Scyllo-Inositol-d6 115268-26-3 98%
    Scyllo-Inositol-d6 is the deuterium labeled Scyllo-Inositol (HY-W010041). Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease.
    Scyllo-Inositol-d6
  • HY-W707780
    Nor mianserin hydrochloride 76134-77-5 99.48%
    Nor mianserin hydrochloride, demethylated derivative of Mianserin (HY-B0188), is a serotonin antagonist. Nor mianserin hydrochloride can be used for the research of diseases related to serotonin metabolism disorders and histamine metabolism disorders.
    Nor mianserin hydrochloride
  • HY-W707863
    Lercanidipine-d3 1190043-34-5 98%
    Lercanidipine-d3 is the deuterium labeled Lercanidipine (HY-B0612). Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective and orally active dihydropyridine-calcium channel blocker with a pIC50 of 7.74 (converts from μM). Lercanidipine has long lasting antihypertensive action as well as reno- and neuro-protective effect. Lercanidipine also shows anti-oxidant, anti-inflammatory and anti-apoptotic properties. Lercanidipine can be used in cardiovascular and neurological research.
    Lercanidipine-d3
  • HY-W707972
    Methapyrilene fumarate 33032-12-1 98%
    Methapyrilene fumarate is a histamine receptor H1 antagonist. Methapyrilene fumarate has sedative effects. Methapyrilene fumarate is being studied for its analgesic properties.
    Methapyrilene fumarate
  • HY-W708196
    Dehydrate haloperidol 52669-92-8 98%
    Dehydrohaloperidol, Haloperidol (HY-14538) analogue, is a selective human dopamine D2 receptor antagonist with a pKd of 8 and a pki of 8. Dehydrohaloperidol can be used for the research of schizophrenia.
    Dehydrate haloperidol
  • HY-W709349
    Flupirtine hydrochloride 33400-45-2 98%
    Flupirtine (D 9998) hydrochloride is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. Flupirtine hydrochloride is a neuronal potassium channel opener (Kv7 activator), a NMDA receptor antagonist and a GABA receptor activator. Flupirtine hydrochloride stabilizes blood-brain-barrier integrity, reduces oxidative stress and brain leukocyte infiltration, enhances angioneurogenesis, suppresses calcium influx, stabilizes neuronal resting membrane potential, and counteracts focal cerebral ischemia. Flupirtine hydrochloride exhibits analgesic, muscle relaxant properties, protects neurons from excitotoxic, ischemic, or cytokine-mediated death. Flupirtine hydrochloride functions as a non-opioid analgesic without antipyretic or antiphlogistic properties, shows no relevant affinity to opiate receptor. Flupirtine hydrochloride can be used for the research of focal cerebral ischemia, pain, Alzheimer’s disease, or multiple sclerosis.
    Flupirtine hydrochloride
  • HY-W709413
    Panaxytriol 87005-03-6 98%
    Panaxytriol is an active component of ginseng. Panaxytriol inhibits the nuclear translocation of NF-κB, thereby reducing the production of pro-inflammatory factors (such as TNF-α, IL-1β, IL-6) and nitric oxide (NO) induced by LPS (HY-D1056). Panaxytriol upregulates CYP3A4 by activating the nuclear receptor PXR/CAR. Panaxytriol improves motor dysfunction in a mouse model of brain inflammation. Panaxytriol can be used in the research of neurodegenerative diseases (such as Alzheimer's disease).
    Panaxytriol
  • HY-W709760
    7-hydroxychlorpromazine 2095-62-7 98%
    7-Hydroxychlorpromazine is an active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine reverses Amphetamine-induced depression of regional compact dopaminergic neurons.
    7-hydroxychlorpromazine
  • HY-W710400
    Quifenadine-d10 2470130-17-5 98%
    Quifenadine-d10 is the deuterium labeled Quifenadine (HY-122761). Quifenadine (Compound 3a), the hydroxyl-(diphenyl)methyl quinuclidine derivative, is a M3 receptor antagonist with an IC50 value > 1000 nM. Quifenadine can be used for the research of neurological disease.
    Quifenadine-d10
  • HY-W712539
    Homodihydrocapsaicin II 71239-21-9 98%
    Homodihydrocapsaicin II is a capsaicinoid with analgesic and anti-inflammatory effects, which is found in capsicum fruits. Homodihydrocapsaicin II is promising for research of inflammatory diseases and neuropathic pain.
    Homodihydrocapsaicin II
Cat. No. Product Name / Synonyms Application Reactivity